… , diabetic nephropathy, hypertensive nephropathy, and glomerulonephritis … transactivation
of EGFR by high glucose leads to collagen synthesis in mesangial cells, and EGFR inhibition …

… This study highlights the importance of Src in diabetic nephropathy. Mesangial cell
proliferation is an important pathological phenomenon in DN (81). High glucose induced the …

… in diabetic nephropathy and elucidate its possible mechanism. … Inhibition of Src kinase
blocks high glucose-induced EGFR transactivation and collagen synthesis in mesangial cells …

… Diabetic nephropathy (DN) is one of the most serious microvascular … -Src is sensitive to
oxidative stress, and inhibition of c-Src activity blocks high glucose-induced EGFR transactivation …

… glomeruli and tubules in patients with diabetic kidney disease (DKD), but its … Src kinase
activity inhibitor PP1 and SU6656 to investigate the effects of Src kinase on EGFR transactivation …

… as diabetic nephropathy, HIV-mediated nephropathy and … Src tyrosine phosphorylation at
Tyr416 in the kidney of mice, … study showed that Src mediates EGFR transactivation after UUO …

… of CHOP in mouse mesangial cells significantly decreased … in mesangial cells is important
in treating diabetic nephropathy. … receptor inhibition slows progression of diabetic nephropathy …

… Mesangial cells (MC) are key in regulating the turnover of the … transactivation of the epidermal
growth factor receptor (EGFR… phosphorylation to high glucose-induced ROS generation, …

… high glucose induced collagen production in mesangial cells … for transactivation of EGFR
in mesangial cells to induce … activation of EGFR in diabetic kidney disease may mediate …

… to the progression of diabetic kidney disease (DKD) remains … of Src kinase in diabetic db/db
mice 12 , STZ-DBA2/J mice 6 , … cytotoxicity assay with renal mesangial cells 10 . Moreover, a …